Heart failure & cardiomyopathies

Papillary Muscle Delayed Hyperenhancement: Prevalence and Clinical Implications in a Large Population With Dilated Cardiomyopathy

JACC AdvPublished Prospective cohort study

Authors' conclusion

The combined presence of myocardial and papHE was independently associated with adverse outcomes.

Study context

Population
Patients with nonischemic dilated cardiomyopathy undergoing late gadolinium enhancement CMR
Participants
528 patients
Exposure
Papillary muscle HE and/or myocardial HE vs neither
Outcome
All-cause mortality, SCD, life-threatening arrhythmia, and HF hospitalization
Follow-up
Median 6.1 years (IQR: 3.7-9.7 years)

Main finding

As reported in the abstract

papHE and myocardial HE vs No papHE, no myocardial HEHazard ratio (95% CI)
All-cause mortality
2.33(1.26–4.30)
SCD
3.77(1.59–8.94)
Life-threatening arrhythmia
3.94(1.34–11.58)
HF hospitalization
2.97(1.30–6.80)

Observational data: associations, not effects.

Further findings

Prevalence of papHE

papHE present
131 patients (25%)

Original publication

Papillary Muscle Delayed Hyperenhancement: Prevalence and Clinical Implications in a Large Population With Dilated Cardiomyopathy. JACC Adv. Published 13 July 2024. doi:10.1016/j.jacadv.2024.101103

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