Heart failure & cardiomyopathies
Parameters associated with improvement of systolic function in patients with heart failure
Authors' conclusion
In this outpatient HFrEF cohort, most patients improved systolic function. Heart failure aetiology, comorbidities and echocardiographic measures of heart structure and function were significantly, independently associated with future LVEF improvement. Greater LVEF improvement was significantly associated with lower mortality.
Study context
- Population
- Outpatients with heart failure with reduced ejection fraction (HFrEF) at the heart failure clinic at Gentofte Hospital
- Participants
- 686 outpatients
- Exposure
- Parameters associated with left ventricular ejection fraction (LVEF) improvement; survival by LVEF improvement
- Δ LVEF >0%n = 559
- Outcome
- Parameters associated with LVEF improvement, and survival according to LVEF improvement
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Baseline parameters associated with LVEF improvement (multivariable linear regression, standardised β-coef)
Δ LVEF >0%
81.5%
559
- Less impaired global longitudinal strain: β-coef 0.25
- P < 0.001
- Higher tricuspid annular plane systolic excursion: β-coef 0.09
- P = 0.018
- Smaller LV internal dimension in diastole: β-coef −0.15
- P = 0.011
- Lower E-wave/A-wave ratio: β-coef −0.13
- P = 0.003
- Higher heart rate: β-coef 0.18
- P < 0.001
- Absence of ischaemic cardiomyopathy: β-coef −0.11
- P = 0.010
- Absence of DM: β-coef −0.081
- P = 0.033
Observational data: associations, not effects.
Further findings
Mortality incidence rate by LVEF improvement
P = 0.012
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Mortality by tertile of LVEF improvementTertile 1vs tertile 3 | 3.23 (1.39–7.51) | P = 0.006 | |
| 0.10.31310Hazard ratio (log scale) |
Original publication
Parameters associated with improvement of systolic function in patients with heart failure. Heart. Published 9 July 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →