Valvular & structural heart disease
Patient characteristics and long-term outcomes in patients undergoing transcatheter aortic valve implantation in a failed surgical prosthesis vs in a native valve: A Danish nationwide study
Authors' conclusion
TAVI in a failed surgical aortic prosthesis as compared to TAVI in a native valve, was not associated with significantly different short- and long-term mortality
Study context
- Population
- All Danish citizens undergoing TAVI, January 1, 2008 to December 31, 2020median age 81
- Participants
- 6,070 participants
- Exposure
- Valve-in-valve TAVI vs native-valve TAVI
- Valve-in-valve-TAVIn = 247
- Outcome
- Risk of death
- Follow-up
- 30 days and 5 years
Methodological detailsnationwide registries
- Nationwide registries
Main finding
As reported in the abstract
Cumulative risk of death
Valve-in-valve-TAVI
- 30-day death
- 2.4% (95% CI: 1.0%-5.0%)
- 5-year death
- 42.5% (95% CI: 34.2%-50.6%)
Native-valve-TAVI
- 30-day death
- 2.7% (95% CI: 2.3%-3.1%)
- 5-year death
- 44.8% (95% CI: 43.2%-46.4%)
30-day death
Valve-in-valve-TAVI2.4% (95% CI: 1.0%-5.0%)
Native-valve-TAVI2.7% (95% CI: 2.3%-3.1%)
5-year death
Valve-in-valve-TAVI42.5% (95% CI: 34.2%-50.6%)
Native-valve-TAVI44.8% (95% CI: 43.2%-46.4%)
Valve-in-valve-TAVI vs Native-valve-TAVIHazard ratio (95% CI)
Death at 30 days; multivariable Cox
0.95(0.41–2.19)
Death at 5 years; multivariable Cox
0.79(0.62–1.00)
Observational data: associations, not effects.
Further findings
Patient characteristics
- Valve-in-valve-TAVI patients younger but greater burden of CV comorbidities vs native-valve-TAVI
Safety
Pacemaker implantation · within 30 days
Original publication
Patient characteristics and long-term outcomes in patients undergoing transcatheter aortic valve implantation in a failed surgical prosthesis vs in a native valve: A Danish nationwide study. Am Heart J. Published 11 May 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →