Valvular & structural heart disease
Prevalence of Aortic Valve Calcium and the Long-Term Risk of Incident Severe Aortic Stenosis
Authors' conclusion
The probability of AVC >0 varied significantly by age, sex, and race/ethnicity. The risk of severe AS was exponentially higher with higher AVC scores, whereas AVC = 0 was associated with an extremely low long-term risk of severe AS.
Study context
- Population
- MESA participants free of known CVD at visit 1, with noncontrast cardiac CT
- Participants
- 6,814 participants
- Exposure
- Aortic valve calcification (AVC) score categories vs AVC = 0
- Outcome
- Prevalence of AVC and its association with long-term incident severe AS
- Follow-up
- Median 16.7 years
Methodological detailsmulti-ethnic, population-based (MESA)
- Multi-ethnic
- Population-based (MESA)
Main finding
As reported in the abstract
Incident severe AS by AVC score
Each group vs AVC = 0Adjusted hazard ratio (95% CI)
AVC 1 to 99
12.9(5.6–29.7)
AVC 100 to 299
76.4(34.3–170.2)
AVC ≥300
380.9(169.7–855.0)
Participants
- AVC present
- 913 (13.4%)
- Incident adjudicated severe aortic stenosis (AS)
- 84
Observational data: associations, not effects.
Further findings
Probability of AVC >0 by age, sex, race/ethnicity
- Probability of AVC >0 and AVC scores increased with age, generally highest among men and White participants
- Probability of AVC >0 in women equivalent to men of same race/ethnicity ≈10 years younger
Original publication
Prevalence of Aortic Valve Calcium and the Long-Term Risk of Incident Severe Aortic Stenosis. JACC Cardiovasc Imaging. Published 10 May 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →