Arrhythmias & electrophysiology
Peak Frequency for Characterizing and Predicting Critical Isthmus and Termination Sites in Macro-Re-Entrant Atrial Tachycardia
Authors' conclusion
Peak frequencies at MRAT termination sites are substantially higher than global atrial PFs, supporting the potential of PF mapping as an effective tool for identifying critical isthmuses in MRAT ablation procedures.
Study context
- Population
- Patients undergoing ablation of macro-re-entrant atrial tachycardia (MRAT) with fully mapped circuits and termination during ablation
- Participants
- 17 patients21 MRATs
- Comparison
- Peak Frequency (PF) at termination sites vs global atrial PF
- Outcome
- Peak frequency (PF)
Methodological detailsconsecutive patients
- Consecutive patients
Main finding
As reported in the abstract
- Max PF at termination sites (mean ± SD)
- 615.2 ± 85.7 Hz
- Global PF (mean ± SD); vs termination sites P < 0.01
- 317.6 ± 45.4 Hz
- PF within 5-mm termination diameter (mean ± SD); vs max at termination P < 0.01
- 499.6 ± 115.4 Hz
- PF threshold differentiating isthmus regions from global atrial PF
- 363 Hz
- PF threshold indicating max PF at termination sites
- >530 Hz
Further findings
Voltage
- Termination sites (mean ± SD)
- 0.39 ± 0.56
- Global average (mean ± SD); P < 0.01
- 0.73 ± 0.57
Ablation lesions required for termination
- Median lesions (Q1-Q3: 1-7)
- 1
- Terminated after initial lesion
- 48%
Original publication
Peak Frequency for Characterizing and Predicting Critical Isthmus and Termination Sites in Macro-Re-Entrant Atrial Tachycardia. JACC Clin Electrophysiol. Published 20 August 2025. doi:10.
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