Arrhythmias & electrophysiology
Prophylactic pulmonary vein isolation in patients with typical atrial flutter and heart failure
Main finding · Composite of death from any cause or hospitalization for worsening HFResult — go to the resultAdjusted hazard ratio 0.37 95% CI 0.17–0.82Authors' conclusion
In this prospective, nonrandomized, controlled study of patients with AFL and HF, prophylactic CPVI was associated with a significantly lower rate of a composite of death from any cause or hospitalization for worsening HF than CTI ablation alone. However, randomized trial verification is required.
Study context
- Population
- Patients with typical atrial flutter (AFL) and heart failure (HF)
- Participants
- 42 vs 39
- Exposure
- Cavotricuspid isthmus (CTI) ablation + circumferential pulmonary vein isolation (CPVI) vs CTI ablation alone
- CTI + CPVI groupn = 42
- CTI-alone groupn = 39reference
- Outcome
- Composite of:
- Death from any cause
- Hospitalization for worsening HF
- Follow-up
- Mean 40.2 ± 12.9 months
Methodological detailsconsecutively enrolled, 9 centers
- Consecutively enrolled
- 9 centers
Main finding
As reported in the abstract
Adjusted hazard ratio
0.37
95% CI 0.17–0.82
P = 0.014
Events by group
CTI + CPVI groupvs CTI-alone group
adjusted hazard ratio 0.37 (95% CI 0.17–0.82); P = 0.014
Observational data: associations, not effects.
Further findings
| Outcome | CTI + CPVI group | CTI-alone group | Adjusted hazard ratio (95% CI) | P value | |
|---|---|---|---|---|---|
| Hospitalization for worsening HF · mean follow-up of 40.2 ± 12.9 months | 26.2% | 48.7% | 0.40 (0.17–0.94) | P = 0.037 | |
| 0.10.31310Adjusted hazard ratio (log scale) |
Baseline characteristics
- Baseline characteristics were balanced between the 2 groups
Original publication
Prophylactic pulmonary vein isolation in patients with typical atrial flutter and heart failure. Heart Rhythm. Published 19 August 2025. doi:10.
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