Periaortic Fat Attenuation on Nongated Noncontrast Chest CT Images to Assess Changes in Arterial Inflammation: Impact of Atorvastatin
Authors' conclusion
Periaortic FA is a marker of atherosclerotic inflammation that can be easily measured on nongated, nonenhanced chest computed tomography images and be used to provide insights into the impact of therapies on atherosclerotic inflammation.
Study context
- Population
- Subjects with risk factors or established atherosclerosissubjects studied
- Participants
- 60 subjects
- Comparison
- High dose atorvastatin
- Atorvastatin 80 mgn = 28
- Atorvastatin 10 mgn = 32
Primary result
As reported in the abstract
Time to assess FA per subject
Time to assess fat attenuation (FA) per subject
88±17 seconds
Further findings
| Outcome | Standardized β | P value |
|---|---|---|
| Change in FA · 12 weeksReduction in FA with high dose | −0.603 | P = 0.010 |
- Change in FA: adjusted for baseline FA, kilovoltage peak, and prior statin use
Correlation of FA with leukopoietic activity · baseline
- Bone marrow
- r =0.412; P =0.021
- Spleen
- r =0.442; P =0.013
Correlation of FA with aortic inflammation (18 F-fluorodeoxyglucose positron emission tomography quintiles) · baseline
- Aortic inflammation
- r =0.274; P =0.043
Original publication
Periaortic Fat Attenuation on Nongated Noncontrast Chest CT Images to Assess Changes in Arterial Inflammation: Impact of Atorvastatin. Circ Cardiovasc Imaging. Published 14 May 2025. doi:10.
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