Development and validation of the CArdiovascular Risk Estimation-Diabetes Mellitus (CARE-DM) model to predict the cardiovascular risk in older persons with type 2 diabetes
Authors' conclusion
The new CARE-DM model allows prediction of the incident CVD risk in older adults with type 2 diabetes.
Study context
- Population
- Adults aged ≥65 years with diabetesmedian age 72 years, 56% women
- Participants
- 6,943 adults
- Outcome
- Incident CVD (accounting for competing risk of non-CV death)
- Follow-up
- 5 years
Methodological details4 population-based prospective cohorts, competing-risk model, 10-fold cross-validation, bootstrapping optimism correction, internal-external cross-validation
- 4 population-based prospective cohorts
- Competing-risk model
- 10-fold cross-validation
- Bootstrapping optimism correction
- Internal-external cross-validation
Performance
As reported in the abstract
Model performance, internal validation with optimism correction
C-index
0.65
95% CI 0.63–0.67
Further findings
Incident cardiovascular disease (CVD) events · median follow-up 6.3 (IQR 3.7, 7.2) years
- Participants with a CVD event: 1204 (17.3%)
Original publication
Development and validation of the CARE-DM model to predict the cardiovascular risk in older persons with type 2 diabetes. Eur J Prev Cardiol. Published 14 May 2025. doi:10.
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