Sex-related variations in platelet reactivity in presence or absence of antiplatelet therapy
Authors' conclusion
Females exhibit heightened baseline ADP-dependent platelet reactivity and a diminished response to aspirin and clopidogrel monotherapy compared to males.
Study context
- Population
- Patients undergoing light transmission aggregometry, with or without antiplatelet therapy, and healthy volunteersincluded after study entry criteria, of 11,913 patients who underwent LTA
- Participants
- 5,687 patients
- Comparison
- Within each group, results were analysed and compared between males and females
- Healthy volunteers (HV)n = 428
- Controls (CTR)n = 1,055
- ASAn = 3,289
- CLOPn = 430
- Dual antiplatelet therapy (DAPT)n = 485
- Outcome
- Platelet reactivity in response to adenosine diphosphate (ADP), females vs males
Methodological detailsstandardized methodology, sequential LTA assessments, 2004–2022
- Standardized methodology
- Sequential LTA assessments, 2004–2022
Main finding
As reported in the abstract
- No significant sex difference in the DAPT group
- Females vs males: P = 0.004
- Females vs males: P < 0.0001
- Females vs males: P < 0.0001
- Females vs males: P < 0.018
Further findings
| Outcome | P value |
|---|---|
| Platelet reactivity in response to collagen, aspirin-treated patientsFemales vs males · increased with females | P < 0.0001 |
Original publication
Sex-related variations in platelet reactivity in presence or absence of antiplatelet therapy. Eur Heart J Cardiovasc Pharmacother. Published 14 May 2025. doi:10.
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