Periodontitis-related myocardial fibrosis by expansion of collagen-producing SiglecF+ neutrophils
Authors' conclusion
This study demonstrated that long-lasting PD-aggravated MI prognosis by expanding scar-associated SiglecF+ neutrophils into the heart
Study context
- Population
- Patients with myocardial infarction (MI) with or without periodontitis (3 prospective cohorts) and PD + MI mouse model3 prospective cohorts
- Comparison
- Periodontitis vs no periodontitis in MI prognosis
Methodological details3 prospective cohorts, PD + MI mouse model
- 3 prospective cohorts
- PD + MI mouse model
Main finding
As reported in the abstract
- Persisting but not short-term PD worsened MI prognosis (cardiac fibrosis and function) in humans and mice
- Bone marrow neutrophils in PD intrinsically skewed toward longer-lived SiglecF+ neutrophil differentiation, converted by GMCSF or TGFβ in a PPARγ-dependent manner
- SiglecF+ neutrophils expanded in infarcted PD heart, depositing collagen and activating fibroblasts to cause excessive fibrosis
- SiglecF+ neutrophil depletion mitigated fibrosis
Original publication
Periodontitis-related myocardial fibrosis by expansion of collagen-producing SiglecF+ neutrophils. Eur Heart J. Published 19 February 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →