Acute cardiac care & resuscitation
Perioperative individualized hemodynamic optimization according to baseline mean arterial pressure in cardiac surgery patients: Rationale and design of the OPTIPAM randomized trial
Study context
- Population
- Patients scheduled for cardiac surgery with cardiopulmonary bypassplanned
- Participants
- 1,100 patients
- Planned comparison
- Individualized mean arterial pressure (MAP) optimization to baseline MAP vs MAP ≥65 mm Hg
- Primary endpoint
- Composite of:
- AKI
- Neurological complications (incl. stroke or postoperative delirium)
- Death
Methodological detailsrationale and design, multicenter, open-label, superiority, two interim safety analyses
- Rationale and design
- Multicenter
- Open-label
- Superiority
- Two interim safety analyses
No results yet. This paper sets out the design of a trial; its results are to come.
Original publication
Perioperative individualized hemodynamic optimization according to baseline mean arterial pressure in cardiac surgery patients: Rationale and design of the OPTIPAM randomized trial. Am Heart J. Published 18 March 2023. doi:10.
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