Arrhythmias & electrophysiology
Persistent atrial fibrillation with left atrial low-voltage area: who benefit from additional modification?
Authors' conclusion
LVA ablation following CPVI may provide additional benefits for older PeAF patients (≥65 years) in the first procedure.
Study context
- Population
- Patients with persistent AF and left atrial low-voltage areas (LVAs) undergoing de novo ablationwith LVAs, of 276 persistent atrial fibrillation (PeAF) patients
- Participants
- 133 patients
- Comparison
- Circumferential pulmonary vein isolation (CPVI) plus LVA ablation vs CPVI alone
- Primary endpoint
- Freedom from atrial arrhythmias after a single ablation procedure
- Follow-up
- 18 months
Methodological detailssubgroup analysis
- Subgroup analysis
Primary result
As reported in the abstract
Atrial arrhythmia recurrence after single ablation, by subgroup (multi-adjusted)
CPVI-plus vs CPVI-aloneHR for atrial arrhythmia recurrence (95% CI)
Age ≥65 years (n = 50)
0.14(0.02–0.83)
- LVA burden ≥15% (n = 18)
- HR for atrial arrhythmia recurrence 0.01 (95% CI 0–0.44)
Further findings
LVA burden ≥15% by age
- Aged ≥65 years: 10 of 50
- 20%
- Aged <65 years: 8 of 83
- 10%
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Persistent atrial fibrillation with left atrial low-voltage area: who benefit from additional modification? Europace. Published 6 May 2025. doi:10.
Summarised from the published abstract; every number is checked against it