Pharmacological preventions and treatments for pericardial complications after open heart surgeries
Pooled result · Postpericardiotomy syndromeResult — go to the resultRelative risk 0.53 95% CI 0.38–0.73Authors' conclusion
The results of our study highly recommend colchicine use to reduce the risk of the postpericardiotomy syndrome and beta-blocker use to reduce postoperative atrial fibrillation. Additionally, our study suggests that further research is needed to investigate other interventions and to evaluate newly proposed interventions in large, high-quality trials, as the current evidence for some interventions is relatively weak.
Study context
- Population
- Adults undergoing major cardiac surgeries
- Participants
- 6,419 adults39 trials
- Comparison
- Pharmacological preventions and treatments compared with control
- Outcome
- Postpericardiotomy syndrome
Methodological detailsfrequentist random-effects network meta-analysis using the restricted maximum likelihood estimator
- Frequentist random-effects network meta-analysis using the restricted maximum likelihood estimator
Pooled result
As reported in the abstract
Relative risk
0.53
95% CI 0.38–0.73
Colchicinevs control
RR 0.53 (95% CI 0.38–0.73)
Further pooled results
| Outcome | RR (95% CI) | |
|---|---|---|
| Atrial fibrillationBeta-blockersvs controlProbably prevent, large magnitude of effect | 0.4 (0.20–0.81) | |
| Postoperative pericarditisBeta-blockersvs controlMay prevent | 0.66 (0.45–0.97) | |
| Postoperative atrial fibrillationFish oilvs control | 0.28 (0.09–0.90) | |
| Postoperative atrial fibrillationNon-steroidal anti-inflammatory drugsvs control | 0.37 (0.23–0.59) | |
| Postoperative atrial fibrillationColchicinevs control | 0.37 (0.23–0.59) | |
| 0.050.21520Relative risk (log scale) |
Pleural effusion, all-cause mortality, postoperative ICU stay
- No evidence of a difference
Original publication
Pharmacological preventions and treatments for pericardial complications after open heart surgeries. Heart. Published 23 January 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →