Heart failure & cardiomyopathies
Phenotype and Prognostic Factors in Geriatric and Non-Geriatric Patients with Transthyretin Cardiomyopathy
Authors' conclusion
These diagnostic and prognostic indicators, along with ATTR subtype, highlight the distinct characteristics of this important, geriatric ATTR-CM patient group.
Study context
- Population
- Patients with transthyretin cardiac amyloidosis (ATTR-CM), wild type (ATTRwt) and hereditary (ATTRv)306 ATTRv, 637 ATTRwt
- Participants
- 943 patients
- Exposure
- Geriatric vs non-geriatric ATTR-CM patients
- Non-geriatricn = 331reference
- Geriatricn = 612
- Outcome
- 3-year survival
- Follow-up
- 3 years
Methodological detailsobservational
- Observational
Main finding
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Predictors of 3-year mortality, geriatric · 3 yearsGeriatricvs Non-geriatricAlkaline phosphatase (ALP) | 1.004 (0.001–1.100) | |
| Predictors of 3-year mortality, geriatric · 3 yearsGeriatricvs Non-geriatricTroponin T hs | 1.005 (1.001–1.120) | |
| Predictors of 3-year mortality, geriatric · 3 yearsGeriatricvs Non-geriatricTricuspid insufficiency | 1.194 (1.02–1.230) | |
| 0.050.21520Hazard ratio (log scale) |
Predictors of 3-year mortality, non-geriatric
| HR (95% CI) | ||
|---|---|---|
| Non-geriatricGlobal longitudinal strain | 0.95 (0.922–0.989) | |
| Non-geriatricGlomerular filtration rate | 0.984 (0.968–1.00) | |
| 0.512Hazard ratio (log scale) |
| Outcome | HR (95% CI) |
|---|---|
| Predictors of 3-year mortality, non-geriatric · NT-proBNP | 1.002 (1.02–1.04) |
Proposed 3-stage prognostic staging (troponin T hs ≥44 ng/L, alkaline phosphatase (ALP) ≥119 UI/L), geriatric survival by stage
- Stage 1
- 82%
- Stage 2
- 50%
- Stage 3
- 32%
- Discriminated survival more precisely than National Amyloidosis Centre staging
Original publication
Phenotype and Prognostic Factors in Geriatric and Non-Geriatric Patients with Transthyretin Cardiomyopathy. ESC Heart Fail. Published 17 July 2024. doi:10.
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