Valvular & structural heart disease
Phenotypic clustering analysis of patients rejected for mitral valve interventions: implications for future transcatheter technologies
Authors' conclusion
This study identified two major subgroups among patients ineligible for mitral interventions showing profound differences in clinical and anatomical profiles. Identifying these factors may drive technological evolution to address the unmet clinical need for therapeutic options in MR patients.
Study context
- Population
- Surgical high-risk patients with mitral regurgitation (MR) screened for transcatheter mitral valve (MV) replacement, ineligible for any MV intervention and receiving medical therapy alonepatients considered ineligible for any MV intervention, registry included 984 screened patients
- Participants
- 284 patients
- Exposure
- PG1 vs PG2
- Outcome
- One-year all-cause mortality
- Follow-up
- One-year
Methodological details33 international sites, unsupervised phenotypic clustering, K-means, unsupervised hierarchical clustering of principal components
- 33 international sites
- Unsupervised phenotypic clustering
- K-means
- Unsupervised hierarchical clustering of principal components
Main finding
As reported in the abstract
P = 0.89
Observational data: associations, not effects.
Further findings
Predictors of mortality
- PG1: albumin, renal function, and extracardiac arteriopathy
- PG2: albumin, coronary artery disease, and prior myocardial infarction
Baseline characteristics of ineligible patients
- Age
- 77.4 ± 8.82 years
- Female
- 56.0%
- EuroSCORE II
- 6.6 ± 5.8%
Original publication
Phenotypic clustering analysis of patients rejected for mitral valve interventions: implications for future transcatheter technologies. Eur Heart J Cardiovasc Imaging. Published 7 May 2025. doi:10.
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