Valvular & structural heart disease
Outcomes Following Transcatheter Mitral Valve Replacement Using Dedicated Devices in Patients With Mitral Annular Calcification
Authors' conclusion
TMVR in patients with MACmod/sev is associated with higher rates of postprocedural complications but similar rates of survival, MR resolution, and functional improvement compared to MACnone/mild.
Study context
- Population
- Patients with symptomatic mitral regurgitation (MR) receiving transcatheter mitral valve replacement (TMVR) with available CT data (CHOICE-MI registry)
- Participants
- 279 patients
- Exposure
- TMVR with dedicated devices in MACmod/sev vs MACnone/mild
- MACmod/sevn = 57
- MACnone/mildn = 222reference
- Outcome
- All-cause mortality
- Follow-up
- 2 years
Methodological detailsmulticentre, consecutive patients
- Multicentre
- Consecutive patients
Main finding
As reported in the abstract
P = 0.76
Observational data: associations, not effects.
Further findings
CV mortality · 2 years
P = 0.97
All-cause mortality or HF hospitalization · 2 years
P = 0.28
Technical success, MR elimination, functional improvement at 1 and 2 years
- Did not differ between groups
Safety
- Higher postprocedural bleeding complications with MACmod/sev
- P = 0.02
- Higher renal failure with MACmod/sev
- P < 0.001
Original publication
Outcomes Following Transcatheter Mitral Valve Replacement Using Dedicated Devices in Patients With Mitral Annular Calcification. JACC Cardiovasc Interv. Published 4 September 2024. doi:10.
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