Heart failure & cardiomyopathies
Phenotyping Patients with Chronic Obstructive Pulmonary Disease and Heart Failure
Main finding · CV death/HF hospitalizationResult — go to the resultHazard ratio 1.15 95% CI 1.11–1.18Authors' conclusion
COPD was present in every eight patient with HF, and more common with preserved EF. Patients with COPD had more severe HF, heavier comorbidity burden and worse morbidity/mortality regardless of EF.
Study context
- Population
- Heart failure (HF) patients in the Swedish HF registry, 2005–2021, across the ejection fraction (EF) spectrum
- Participants
- 97,904 patients
- Exposure
- Chronic obstructive pulmonary disease (COPD) vs no COPD
- Outcome
- COPD prevalence, patient profiles and outcomes (CV death/HF hospitalization) across the EF spectrum
Methodological detailsSwedish HF registry, multivariable logistic and Cox regression
- Swedish HF registry
- Multivariable logistic and Cox regression
Main finding
CV death/HF hospitalization
Hazard ratio
1.15
95% CI 1.11–1.18
COPDvs No COPD
HR 1.15 (95% CI 1.11–1.18)
As reported in the abstract
- COPD prevalence, overall
- 13%
- COPD prevalence, HFpEF
- 16%
- COPD prevalence, HF with mildly reduced EF (HFmrEF)
- 12%
- COPD prevalence, HF with reduced EF (HFrEF)
- 11%
Observational data: associations, not effects.
Further findings
Cardiovascular (CV) death, non-CV death, all-cause death, HF hospitalizations
- COPD independently associated with higher risk, regardless of EF
Characteristics independently associated with COPD
- Higher EF, female sex, smoking, obstructive sleep disorder, PAD, lower educational level, more severe HF, more likely MRA and diuretic use
- Less likely use of ACEi/ARB/ARNI (not in HFrEF), beta-blockers, HF device therapies and follow-up in HF nurse-led clinics
Original publication
Phenotyping Patients with Chronic Obstructive Pulmonary Disease and Heart Failure. ESC Heart Fail. Published 7 November 2024. doi:10.
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