Arrhythmias & electrophysiology
Physical activity and risk of adverse events in atrial fibrillation: evidence from European and Asian cohorts
Primary result · Composite of all-cause death and MACEResult — go to the resultHazard ratio 0.66 95% CI 0.56–0.78Authors' conclusion
In patients with AF, self-reported physical activity is associated with a lower risk of adverse events, consistently across Europe and Asia.
Study context
- Population
- Patients with atrial fibrillation (AF) in European and Asia-Pacific registries
- Participants
- 13,126 patients
- Comparison
- Physically active vs physically inactive patients with AF
- Activen = 3,639
- Inactiven = 9,487reference
- Primary endpoint
- Composite of:
- All-cause death
- Major adverse cardiovascular events (MACE)
- Follow-up
- Median 514 days
Methodological detailsEurope and Asia-Pacific
- Europe and Asia-Pacific
Primary result
Composite of:
Hazard ratio
0.66
95% CI 0.56–0.78
Active vs Inactive
HR 0.66 (95% CI 0.56–0.78)
As reported in the abstract
Secondary outcomes
| Outcome | HR (95% CI) | |
|---|---|---|
| All-cause death | 0.52 (0.42–0.65) | |
| MACE | 0.80 (0.65–0.99) | |
| CV death | 0.60 (0.42–0.86) | |
| 0.512Hazard ratio (log scale) |
Composite outcome by level of physical activity
- Risk decreased progressively with increasing physical activity, no significant difference between Europeans and Asians
- P for interaction = 0.845
Original publication
Physical activity and risk of adverse events in atrial fibrillation: evidence from European and Asian cohorts. Europace. Published 1 March 2026. doi:10.
Summarised from the published abstract; every number is checked against it