Physical Activity During Breast Cancer Therapy Associates With Preserved Exercise Capacity and Cardiac Function (WF97415)
Authors' conclusion
PA declined during BC therapy; however, PA participation was associated with attenuated declines in exercise capacity and cardiac function that are often observed in this population.
Study context
- Population
- Women with stage I–III breast cancer undergoing treatment, and controls
- Participants
- 223 vs 126
- Exposure
- Greater vs less leisure-time physical activity during breast cancer therapy
- Breast cancer (BC)n = 223
- Controln = 126reference
- Outcome
- Submaximal exercise capacity (6-minute walk distance) and cardiac function (CMR) by leisure-time PA
- Follow-up
- 3 months
Main finding
As reported in the abstract
Odds ratio (95% CI)
Increased LTPA over 3 monthstreatment-induced cardiac dysfunction by LV circumferential strain
0.98(0.97–0.998)
- More Leisure-time PA (LTPA) · exercise capacity
- β ± SE 7.1 ± 1.6 (95% CI 4.0–10.1)
- More LTPA · left ventricular (LV) circumferential strain
- β ± SE −0.16 ± 0.07 (95% CI −0.29 to −0.02)
Observational data: associations, not effects.
Further findings
| Outcome | BC | Control | Estimate | P value |
|---|---|---|---|---|
| LTPA score · baseline | 24.7 (95% CI 21.7–28.0) | 29.4 (95% CI 25.0–34.2) | ||
| LTPA score · 3 months | 16.9 (95% CI 14.4–19.6) | 30.8 (95% CI 26.2–35.8) | ||
| Change in BC participants with insufficient LTPA per PA guidelinesInsufficient LTPA · exercise capacity | adjusted mean difference ± SE −29 ± 10 m | P = 0.029 | ||
| Change in BC participants with insufficient LTPA per PA guidelinesInsufficient LTPA · LV end-systolic volume | adjusted mean difference ± SE 5.8 ± 1.3 mL | P < 0.001 | ||
| Change in BC participants with insufficient LTPA per PA guidelinesInsufficient LTPA · LVEF | adjusted mean difference ± SE −3.2% ± 0.8% | P = 0.002 | ||
| Change in BC participants with insufficient LTPA per PA guidelinesInsufficient LTPA · LV circumferential strain | adjusted mean difference ± SE 2.5% ± 0.5% | P < 0.001 |
LTPA score · baseline
- Similar baseline LTPA scores
Change in BC participants with insufficient LTPA per physical activity (PA) guidelines
- BC participants meeting LTPA guidelines did not exhibit these adverse changes
Original publication
Physical Activity During Breast Cancer Therapy Associates With Preserved Exercise Capacity and Cardiac Function (WF97415). JACC CardioOncol. Published 21 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →