Valvular & structural heart disease
Physician assessment of aortic stenosis severity, quantitative parameters, and long-term outcomes: Results from the KP-VALVE project
Authors' conclusion
Physician-assessed AS severity predicts outcomes, with cumulative effects for each severe AS parameter. Moderate AS includes a wide spectrum of patients, with discordant AVA <1.0 cm2 being both common and predictive.
Study context
- Population
- Patients with aortic stenosis (AS) (physician-assessed severity and echocardiographic parameters), KP-VALVE project, 2008–201849,604 with AS
- Participants
- 546,769 patients
- Exposure
- Physician-assessed AS severity and number of quantitative severe AS parameters
- Outcome
- Death, CV hospitalization and aortic valve replacement
- Follow-up
- Median 3.7 [IQR 1.7-6.8] years
Main finding
As reported in the abstract
Death, by number of quantitative severe AS parameters
Adjusted hazard ratio (95% CI)
1 severe AS parameter
1.40(1.34–1.46)
2 severe AS parameters
1.70(1.56–1.85)
3 severe AS parameters
1.78(1.63–1.94)
Observational data: associations, not effects.
Further findings
AS severity distribution among AS patients
- Moderate AS
- 17.6%
- Moderate-severe AS
- 3.6%
- Severe AS
- 9.4%
- Mean [SD] age 77 [11] years
Aortic valve area <1.0 cm²
- Most frequent severe AS parameter; largest relative contribution to outcomes
- 67%
- Present in patients classified as moderate AS
- 21%
- Present in patients classified as moderate-severe AS
- 56%
Original publication
Physician assessment of aortic stenosis severity, quantitative parameters, and long-term outcomes: Results from the KP-VALVE project. Am Heart J. Published 6 August 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →