Blood DNA methylation signature of diet quality and association with cardiometabolic traits
Authors' conclusion
Diet quality in adults was related to differential methylation in blood at 18 CpGs, some of which related to cardiometabolic health.
Study context
- Population
- Adults in four cohorts from Spain, the US and the UK
- Participants
- 5,274 adults · 4 cohorts
- Comparison
- Diet quality scores and blood DNA methylation
- Outcome
- CpGs whose blood DNA methylation is associated with diet quality scores
Methodological details4 cohorts, Spain, US, UK
- 4 cohorts
- Spain, US, UK
Pooled result
As reported in the abstract
Diet-associated differentially methylated CpGs
Differentially methylated cytosine-phosphate-guanine (CpGs) associated with dietary scores
18
Of these, previously associated with cardiometabolic traits
12
Further pooled results
Pathway enrichment
- Diet-associated genes overrepresented in inflammation and CVD pathways
Mendelian randomization: diet-related CpGs and cardiometabolic traits
- Methylation for lower diet quality at cg02079413 (SNORA54), cg02107842 (MAST4), cg23761815 (SLC29A3) causally associated with higher body mass index (BMI)
- Methylation for lower diet quality at cg05399785 (WDR8) causally associated with greater systolic blood pressure (SBP)
- Methylation for higher diet quality at cg00711496 (PRMT1) associated with lower BMI, T2DM risk and coronary heart disease (CHD) risk
- Methylation for higher diet quality at cg0557921 (AHRR) associated with lower CHD risk
Original publication
Blood DNA methylation signature of diet quality and association with cardiometabolic traits. Eur J Prev Cardiol. Published 4 October 2023. doi:10.
Summarised from the published abstract; every number is checked against it