Heart failure & cardiomyopathies
Plasma myeloperoxidase and echocardiographic markers of impaired diastolic function in healthy individuals
Authors' conclusion
In a population setting, high MPO and SUA, indicative of high bioactive MPO, were associated with early markers of diastolic dysfunction, suggesting a potential role of the MPO pathway in the early development of HFpEF.
Study context
- Population
- Initially healthy individuals (STANISLAS cohort, fourth visit), age 49±14 years, 48% male
- Participants
- 1,677 participants
- Exposure
- High myeloperoxidase (MPO) and high serum uric acid (SUA) compared with low MPO and low SUA
- Outcome
- Baseline characteristics
Main finding
As reported in the abstract
- Participants with high MPO and high SUA were older, had more diabetes, a higher body mass index, lower estimated glomerular filtration rate and higher systolic blood pressure
Observational data: associations, not effects.
Further findings
| Outcome | mean±SE | P value |
|---|---|---|
| Left atrial reservoir strainHigh MPO and high SUA vs low MPO and low SUA · decreased · multivariable regression | −1.43±0.62 | P = 0.022 |
| Mitral annular e’ velocityHigh MPO and high SUA vs low MPO and low SUA · decreased · multivariable regression | −0.60±0.16 | P < 0.001 |
| Left ventricular systolic global longitudinal strainHigh MPO and high SUA vs low MPO and low SUA · more impaired · multivariable regression | 0.50±0.23 | P = 0.029 |
Diastolic function, high MPO with low SUA
- High MPO with low SUA was not associated with impaired diastolic function
Original publication
Plasma myeloperoxidase and echocardiographic markers of impaired diastolic function in healthy individuals. Heart. Published 11 July 2025. doi:10.
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