Heart failure & cardiomyopathies
Layer myocardial strain is the most heritable echocardiographic trait
Authors' conclusion
In our population cohort, GLSEndo/GLSEpi ratio had a high level of heritability, whereas other classical and mechanical LV function parameters did not.
Study context
- Population
- Initially healthy subjects of the longitudinal familial STANISLAS cohort (Lorraine, France), 20-year follow-up after the fourth visitwomen 51.6%
- Participants
- 1,357 subjects
- Outcome
- Heritability of echocardiographic cardiac mechanics indices (layer-specific global longitudinal strain (GLS) and global circumferential strain) and conventional structural and functional cardiac parameters
Methodological detailsheritability analysis, longitudinal familial cohort, restricted maximum likelihood analysis, genetic relatedness matrix from genome-wide association data, Echocardiography per EACVI/ASE/Industry Task Force acquisition and measurement protocols
- Heritability analysis
- Longitudinal familial cohort
- Restricted maximum likelihood analysis
- Genetic relatedness matrix from genome-wide association data
- Echocardiography per EACVI/ASE/Industry Task Force acquisition and measurement protocols
Main finding
As reported in the abstract
Heritability of echocardiographic traits
- GLSEndo/GLSEpi ratio heritability (high)
- 65%
- Longitudinal/circumferential myocardial function indices and LVEF heritability (low)
- 10% to 20%
- Diastolic and standard left ventricular (LV) function parameters heritability (moderate)
- 20% to 30%
- End-systolic volume heritability
- 30%
- End-diastolic volume heritability
- 45%
- Unexplained variance, all traits except GLSEndo/GLSEpi ratio
- >50%
Observational data: associations, not effects.
Original publication
Layer myocardial strain is the most heritable echocardiographic trait. Eur Heart J Cardiovasc Imaging. Published 23 June 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →