Heart failure & cardiomyopathies
Protein biomarkers associated with left bundle branch block in patients with heart failure and reduced ejection fraction
Authors' conclusion
In HFrEF, LBBB was associated with an altered circulating proteome. FGF2 and EGFR were highly dysregulated between the groups and the MAPK signalling pathway was affected, all of which may be pathophysiologically involved in the accelerated cardiac remodelling observed in these patients. These findings constitute a foundation for future studies of relevant LBBB-related biomarkers, treatment targets, and mechanisms behind the cardiac remodelling observed when LBBB is superimposed on HFrEF.
Study context
- Population
- Patients with Heart Failure with Reduced Ejection Fraction (HFrEF) from the BIOlogy Study to TAilored Treatment in Chronic Heart Failure databasedatabase, 268 cases and 268 matched controls
- Participants
- 4,254 patients
- Comparison
- Relative plasma concentrations of 364 proteins between the two groups
- HFrEF + left bundle branch block (LBBB)n = 268
- HFrEF - LBBBn = 268
- Outcome
- Plasma proteins up- or downregulated
Methodological detailsomics approach, proximity extension assay
- Omics approach
- Proximity extension assay
Main finding
As reported in the abstract
Proteins up- or downregulated in HFrEF + LBBB compared with HFrEF - LBBB, out of 364 assessed
41
Share of proteins assessed
11%
Further findings
Gene ontology pathway enrichment among upregulated proteins
- Mainly involved in immune response and cell signalling and included the mitogen-activated protein kinase (MAPK) pathway
Original publication
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