Coronary disease & ACSCohort study
Plasma proteome and incident myocardial infarction: sex-specific differences
- Prospective cohort study with Mendelian randomisation analysis
- discovery and replication cohorts
Authors' conclusion
This study identified both new and confirmed previously established associations between circulating proteins and incident MI and, for the first time, suggested sex-specific patterns in multiple protein-MI associations.
Study context
- Population
- Swedish adults aged 55–93 years; replication in UK Biobankreplication n = 51,613
- Participants
- 11,751 adults
- Outcome
- Incident MI
- Follow-up
- 8 years
Main finding
As reported in the abstract
Proteins associated with incident MI
Proteins associated with incident myocardial infarction (MI) in discovery and replication samples after adjustment for confounders and multiple testing
45
Observational data: associations, not effects.
Further findings
Sex-specific protein associations
- Sex-specific protein associations, most among women
- 13
Mendelian randomization (MR) analysis
- Genetically predicted higher renin, follistatin and retinoic acid receptor responder protein 2 linked to increased MI risk
- Tissue factor pathway inhibitor, TNF receptors 1 and 2, placenta growth factor inversely associated with MI
Original publication
Plasma proteome and incident myocardial infarction: sex-specific differences. Eur Heart J. Published 14 October 2024. doi:10.1093/eurheartj/ehae658
Summarised from the published abstract; every number is checked against it