Heart failure & cardiomyopathies
Plasma Proteomic Patterns Show Sex Differences in Early Concentric Left Ventricular Remodeling
Authors' conclusion
cRM is prevalent in approximately 1 in 4 women and men visiting outpatient cardiology clinics and associated with HFpEF development and mortality risk in both sexes. Known risk factors for cRM were more strongly associated in women than men. Proteomic analysis revealed inflammatory pathway activation in women, with a central role for IFNA5.
Study context
- Population
- Patients visiting outpatient clinics of Cardiology Centers of the Netherlands54.2% women
- Participants
- 60,593 patients
- Comparison
- Women vs men
- Primary endpoint
- Concentric remodeling (cRM): prevalence, association with heart failure with preserved ejection fraction (HFpEF) development and mortality; risk factors for relative wall thickness
Methodological detailssex-stratified analysis, multicentre
- Sex-stratified analysis
- Multicentre
Primary result
As reported in the abstract
cRM prevalence
cRMHazard ratio (95% CI)
Developing HFpEF, both sexes
2.15(1.51–2.99)
Mortality, both sexes
1.09(1.00–1.19)
Further findings
Risk factors for relative wall thickness
- Age, heart rate and hypertension significantly stronger risk factors in women than men
Proteomics (4534 plasma proteins; substudy n=557, 65.4% women)
- Higher IFNA5 levels associated with higher relative wall thickness in women only
- Differential pathway activation by sex; increased inflammatory pathway expression in women
Original publication
Plasma Proteomic Patterns Show Sex Differences in Early Concentric Left Ventricular Remodeling. Circ Heart Fail. Published 29 June 2023. doi:10.
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