Arrhythmias & electrophysiology
Plasma small extracellular vesicles: Markers and mediators of atrial scar, in patients with atrial fibrillation
Authors' conclusion
EVs are markers of LVA with effects on atrial fibroblasts. They add prognostic value to FABP4 and galectin-3 levels for AF recurrence.
Study context
- Population
- Patients with long-standing persistent AF undergoing pulmonary vein isolation (PVI) and electroanatomic mapping
- Participants
- 104 patients
- Outcome
- Plasma EV proteome profile associated with high % low-voltage area (LVA)
Methodological detailsconsecutive patients
- Consecutive patients
Main finding
As reported in the abstract
EV protein cargo identified patients with high % low-voltage area (LVA)
70%
Original publication
Plasma small extracellular vesicles: Markers and mediators of atrial scar, in patients with atrial fibrillation. Heart Rhythm. Published 8 September 2025. doi:10.
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