Plasma soluble TREM-1 and risk of cardiovascular disease in the population. Results from the Paris Prospective Study III and the CoLaus|PsyCoLaus
An erratum to this article was published (Eur J Prev Cardiol, 29 Jul 2026 ↗)
Authors' conclusion
In this prospective study, higher circulating sTREM-1 levels were independently associated with incident CVD. Addition of sTREM-1 to established risk scores was associated with improvements in discrimination and reclassification metrics
Study context
- Population
- Cardiovascular disease (CVD)-free adults (39% females, mean age 59.6±6.3 years)CVD-free
- Participants
- 9,097 adults
- Exposure
- sTREM-1 concentration categories
- Outcome
- Incident CVD
- Follow-up
- Median 10.1 years
Methodological detailsobservational
- Observational
Main finding
As reported in the abstract
Hazard ratio (95% CI)
200-290vs <200pg/ml
4.25(3.20–5.63)
>290vs <200pg/ml
10.40(7.72–14.02)
- Participants with CVD events
- 444
- CVD events
- 479
Observational data: associations, not effects.
Further findings
| Outcome | Bootstrapped C index difference (95% CI) | |
|---|---|---|
| Discrimination: sTREM-1 added to SCORE2-SCORE2 OP (Harell C-index)SCORE2-SCORE2 OP + sTREM-1vs SCORE2-SCORE2 OPC-index 0.79 vs. 0.71 | 0.084 (0.083–0.085) | |
| −0.0500.050.1Difference (linear scale) |
| Outcome | Categorical NRI (95% CI) |
|---|---|
| Reclassification: sTREM-1 added to SCORE2-SCORE2 OPSCORE2-SCORE2 OP + sTREM-1 vs SCORE2-SCORE2 OP | 0.34 (0.28–0.40) |
Discrimination: sTREM-1 added to SCORE2-SCORE2 OP (Harell C-index)
- Improvement also among individuals at low to moderate 10-year risk of CHD or stroke
Reclassification: sTREM-1 added to SCORE2-SCORE2 OP
- Findings similar with other recommended risk scores
CVD subtypes
- Results consistent across CVD subtypes
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Plasma soluble TREM-1 and risk of cardiovascular disease in the population. Results from the Paris Prospective Study III and the CoLaus|PsyCoLaus. Eur J Prev Cardiol. Published 12 May 2026. doi:10.
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