Heart failure & cardiomyopathiesCohort study
Surgical myectomy for hypertrophic cardiomyopathy: procedural volume and outcomes
- Retrospective cohort study
- multicentre
- registry-based (Netherlands Heart Registration)
- 12 Dutch hospitals
Authors' conclusion
Surgical myectomy with or without concomitant procedures effectively relieved LVOT obstruction in 93% of patients in this multicentre cohort. Female sex, ≥ 2 concomitant procedures, and low-volume hospitals were associated with higher 30-day complication rates.
Study context
- Population
- Hypertrophic obstructive cardiomyopathy (HOCM) patients undergoing surgical myectomy, 12 Dutch hospitals, 2012–2020
- Participants
- 335 patients
- Exposure
- Low-volume vs higher-volume hospitals (and other factors) for 30-day complications after surgical myectomy
- Outcome
- 30-day clinical outcomes and factors associated with increased 30-day complication rates
- Follow-up
- 30 days
Main finding
30-day complications
Odds ratio
3.23
95% CI 1.43–8.09
P = 0.007
Low-volume vs higher-volume hospitals (and other factors) for 30-day complications after surgical myectomy
OR 3.23 (95% CI 1.43–8.09); P = 0.007
As reported in the abstract
- 30-day mortality
- 5%
- 30-day ventricular septal defect
- 2%
- 30-day stroke
- 3%
- 30-day surgical reoperation
- 2%
Observational data: associations, not effects.
Further findings
Haemodynamic and valvular changes after myectomy · postoperatively
- Mean resting left ventricular outflow tract (LVOT) gradient, before → after
- 61 ± 30 mmHg to 13 ± 12 mmHg
- Systolic anterior motion, before → after
- 80% to 8%
- Mitral regurgitation grade 3 or 4, before → after
- 31% to 6%
Procedure type
- Isolated myectomy
- 22%
- Myectomy + one concomitant procedure
- 54%
- Myectomy + ≥2 concomitant procedures
- 24%
Original publication
Surgical myectomy for hypertrophic cardiomyopathy: procedural volume and outcomes. Eur Heart J. Published 29 August 2025. doi:10.1093/eurheartj/ehaf560
Summarised from the published abstract; every number is checked against it