Arrhythmias & electrophysiology
Pocket histology at cardiac implantable electronic device replacement: What’s new?
Authors' conclusion
The CIED pocket is a histopathologically dynamic environment, given the coexistence of both a subacute foreign body response and fibrous tissue growth, implying continuous remodeling due to an injury-repair mechanism.
Study context
- Population
- Patients undergoing cardiac implantable electronic device (CIED) replacement or upgrade, without subclinical pocket infection6 women [20%]
- Participants
- 30 patients
- Outcome
- CIED pocket histology (capsular thickness, fibrous connective tissue, neovascularization, inflammation, calcifications)
Methodological detailssingle-centre, consecutive patients, Specimens from anterior and posterior pockets obtained intraoperatively, November 2019 to May 2020
- Single-centre
- Consecutive patients
- Specimens from anterior and posterior pockets obtained intraoperatively, November 2019 to May 2020
Main finding
As reported in the abstract
Capsular thickness
- Subacute exudative fibrous inflammation in posterior pocket wall
- a quarter of cases
Observational data: associations, not effects.
Original publication
Pocket histology at cardiac implantable electronic device replacement: What’s new? Heart Rhythm. Published 26 October 2022. doi:10.
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