Polycystic Ovary Syndrome Fuels Cardiovascular Inflammation and Aggravates Ischemic Cardiac Injury
Authors' conclusion
PCOS may promote myocardial macrophage accumulation and post-MI cardiac remodeling because of augmented splenic myelopoiesis.
Study context
- Population
- Mouse models of polycystic ovary syndrome (PCOS), incl. Myocardial infarction (MI) by permanent coronary ligation; women with PCOS and controlswomen, PCOS and controls
- Participants
- 200 participants
- Comparison
- PCOS vs control
Methodological detailsmouse models of PCOS, parabiosis, human confirmation cohort
- Mouse models of PCOS
- Parabiosis
- Human confirmation cohort
Main finding
As reported in the abstract
- Increased macrophage accumulation in PCOS mouse hearts
- Monocyte-derived macrophages significantly increased in PCOS mouse hearts due to enhanced circulating Ly6C+ monocyte supply
- Significant increase in splenic Ly6C+ monocyte output in PCOS mice, with elevated splenic hematopoietic progenitors and sympathetic tone
- Plasma norepinephrine and spleen size increased in women with PCOS vs controls; norepinephrine significantly correlated with circulating CD14++CD16- monocyte counts
- Significantly exacerbated atherosclerotic plaque development and post-MI cardiac remodeling in PCOS animals
- Conditional Vcam1 silencing in PCOS mice significantly suppressed cardiac inflammation and improved cardiac injury after MI
Original publication
Polycystic Ovary Syndrome Fuels Cardiovascular Inflammation and Aggravates Ischemic Cardiac Injury. Circulation. Published 8 November 2023. doi:10.
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