Heart failure & cardiomyopathies
Population attributable risk of traditional, under-recognised and female-specific factors for heart failure in women
Authors' conclusion
A combination of modifiable, psychosocial, environmental and reproductive risk factors accounts for two-thirds of HF cases in women. Tailored, life course-oriented prevention strategies are essential to reduce this burden.
Study context
- Population
- Women from the UK Biobankwomen, median follow-up 13.7 years
- Participants
- 233,125 women
- Comparison
- 22 risk factors grouped as well-established, under-recognised or female-specific, and their contribution to incident heart failure (HF)
- Outcome
- Incident HF
- Follow-up
- Median 13.7 years
Methodological detailsPopulation attributable fractions (PAFs), UK Biobank, stratified by age and obesity
- PAFs
- UK Biobank
- Stratified by age and obesity
Main finding
As reported in the abstract
Women who developed HF
6077
Further findings
Share of HF cases by risk-factor domain
Overall PAF for all risk factors
- Overall PAF
- 66.0%
Largest individual contribution: hypertension
- Hypertension PAF
- 25.3%
Key reproductive drivers
- Chronic inflammatory diseases, early age at menopause and early age at first birth were key reproductive drivers
Age-stratified HF burden
- Highest HF burden in women aged 55-59 years (PAF)
- 70.0%
Original publication
Population attributable risk of traditional, under-recognised and female-specific factors for heart failure in women. Heart. Published 4 August 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →