Heart failure & cardiomyopathies
Left ventricular septal pacing combined with left ventricular pacing improves acute electric resynchronization, hemodynamic responses and clinical outcomes: results of SPORT study
Authors' conclusion
LVSP combined with LVP might offer greater AHR, electrical resynchronization and as well as improved clinical outcomes than LVSP alone in patients undergoing LBBAP-CRT without LBB capture.
Study context
- Population
- Patients undergoing LBBAP-CRT without confirmed LBB capture
- Participants
- 45 patients
- Exposure
- Left ventricular septal pacing (LVSP) + LVP vs LVSP alone
- LVSP + LVPn = 20
- LVSPn = 25reference
- Outcome
- QRS duration (QRSd) reduction
Methodological detailsconsecutive patients
- Consecutive patients
Main finding
As reported in the abstract
LVSP + LVP
46.2
mean · SD 19.2 · ms
LVSP
32.6
mean · SD 23.0 · ms
P = 0.049
Observational data: associations, not effects.
Further findings
| Outcome | Mean difference (%) (95% CI) | P value | |
|---|---|---|---|
| LVEF improvement · median follow-up 26 months | 3.05 (0.05–6.05) | P = 0.047 | |
| −50510Difference, % (linear scale) |
| Outcome | aHR (CI) | P value | |
|---|---|---|---|
| Clinical outcomes (all-cause mortality, HF hospitalization, ventricular tachyarrhythmias) · median follow-up 26 months87% lower risk | 0.13 (0.03–0.62) | P = 0.011 | |
| 0.050.21520Adjusted hazard ratio (log scale) |
Mean, %
| Outcome | LVSP + LVP | LVSP | P value |
|---|---|---|---|
| Improvement in AHR (LV dP/dtmax) | 20.0 (SD 9.2) | 10.4 (SD 8.2) | P＜0.001 |
- Improvement in acute hemodynamic response (AHR) (LV dP/dtmax): in 10 patients
Original publication
Left ventricular septal pacing combined with left ventricular pacing improves acute electric resynchronization, hemodynamic responses and clinical outcomes: results of SPORT study. Europace. Published 4 August 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →