Heart failure & cardiomyopathies
Predicted Deleterious Variants in Cardiomyopathy Genes Prognosticate Mortality and Composite Outcomes in the UK Biobank
Main finding · All-cause mortalityResult — go to the resultHazard ratio 1.13 95% CI 1.01–1.25Authors' conclusion
Adults with predicted deleterious variants in cardiomyopathy-associated genes exhibited a slightly higher risk of mortality and a significantly increased risk of developing cardiomyopathy, and cardiomyopathy-related composite outcomes, in comparison with genotype-negative controls.
Study context
- Population
- UK Biobank participants with whole exome sequencing data
- Participants
- 200,619 participants
- Exposure
- CMP-G+ vs CMP-G-
- CMP-G+n = 5,292
- Outcome
- All-cause mortality
Methodological detailspopulation-based, whole exome sequencing
- Population-based
- Whole exome sequencing
Main finding
As reported in the abstract
Hazard ratio
1.13
95% CI 1.01–1.25
P = 0.027
CMP-G+vs CMP-G-
HR 1.13 (95% CI 1.01–1.25); P = 0.027
Observational data: associations, not effects.
Secondary outcomes
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Diagnosis of cardiomyopathyAdjusted for age and sex · consistent across all cardiomyopathy subgroups | 5.75 (4.58–7.23) | P < 0.0001 | |
| Composite of cardiomyopathy diagnosis, HF, arrhythmia, stroke and deathAdjusted for age and sex · consistent across all cardiomyopathy subgroups | 1.29 (1.20–1.39) | P < 0.0001 | |
| 0.10.31310Hazard ratio (log scale) |
Original publication
Predicted Deleterious Variants in Cardiomyopathy Genes Prognosticate Mortality and Composite Outcomes in the UK Biobank. JACC Heart Fail. Published 13 September 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →