Valvular & structural heart disease
Predicted prosthesis–patient mismatch and long-term clinical outcomes after transcatheter aortic valve replacement: A SWEDEHEART study
Authors' conclusion
The risk of all-cause mortality, heart failure hospitalization, or aortic valve reintervention was not higher in patients with than without predicted PPM following TAVR. Furthermore, PPM was present in only 7% of patients, and severe PPM was almost nonexistent.
Study context
- Population
- All patients undergoing transfemoral primary transcatheter aortic valve replacement (TAVR) in Sweden, 2008–2022mean follow-up 3.0 years
- Participants
- 8,485 patients
- Exposure
- Predicted prosthesis-patient mismatch (PPM) vs no PPM after TAVR
- PPMn = 606
- No PPMn = 7,879reference
- Outcome
- All-cause mortality, HF hospitalization and aortic valve reintervention
Methodological detailsnationwide, SWEDEHEART register, regression standardization
- Nationwide
- SWEDEHEART register
- Regression standardization
Main finding
As reported in the abstract
All-cause mortality · 1, 5 and 10 years
Crude cumulative incidence, 1 year
Crude cumulative incidence, 5 years
Crude cumulative incidence, 10 years
- No between-group difference in long-term mortality after regression standardization; absolute difference at 10 years
- 1.5% (95% CI −2.9%-6.0%)
Observational data: associations, not effects.
Original publication
Predicted prosthesis–patient mismatch and long-term clinical outcomes after transcatheter aortic valve replacement: A SWEDEHEART study. Am Heart J. Published 18 July 2024. doi:10.
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