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Valvular & structural heart diseaseCohort study

Impact of Measured and Predicted Prosthesis-Patient Mismatch After Transcatheter Aortic Valve Replacement

JACC Cardiovasc IntervPublished

  • Registry cohort study
  • multicentre
  • international (26 centres)
Read the original article ↗

Authors' conclusion

After adjusting for confounders, neither PPMm nor PPMp significantly affected 2-year all-cause mortality.

Study context

Population
Patients undergoing transcatheter aortic valve replacement (TAVR), IMPPACT TAVR registry, 26 international centres
Participants
38,808 patients · 26 centres
Exposure
Measured vs predicted prosthesis-patient mismatch after TAVR
Outcome
All-cause mortality
Follow-up
2 years

Main finding

As reported in the abstract

2-year all-cause mortality
unadjusted
Hazard ratio (95% CI)P value
Severe PPMm
1.22(1.02–1.45)
P = 0.027
Severe PPMp
0.81(0.55–1.19)
P = 0.291

Observational data: associations, not effects.

Further findings

Prevalence of PPM · prevalence significantly lower with PPMp

P < 0.001

Moderate

Severe

Prevalence of PPM — Correlation between methods negligible (Kendall's tau c)
0.063
  • Prevalence of PPM: Kendall's tau c P < 0.001

Original publication

Impact of Measured and Predicted Prosthesis-Patient Mismatch After Transcatheter Aortic Valve Replacement. JACC Cardiovasc Interv. Published 25 November 2024. doi:10.1016/j.jcin.2024.08.041
Read the original article ↗PubMedCite RIS · BibTeX

Summarised from the published abstract; every number is checked against it