Valvular & structural heart disease
Prediction of mortality and heart failure hospitalisations in patients undergoing mitral transcatheter edge-to-edge repair (M-TEER): external validation of the COAPT risk score
Authors' conclusion
The COAPT risk score has a poor performance in the prognostic stratification of real-world patients undergoing M-TEER. However, after application to patients with a COAPT-like profile, moderate discrimination and good calibration were observed.
Study context
- Population
- Patients undergoing M-TEER for secondary mitral regurgitation, Italian GIOTTO registryof 1,659 in registry
- Participants
- 934 patients
- Comparison
- COAPT risk score quartiles
- Outcome
- All-cause death or HF hospitalisation; COAPT score discrimination and calibration
- Follow-up
- 2 years
Methodological detailsmulticentre registry
- Multicentre registry
Performance
As reported in the abstract
2-year all-cause death or HF hospitalisation, overall population
P < 0.001
Further findings
2-year all-cause death or HF hospitalisation, COAPT-like patients
P = 0.004
2-year all-cause death or heart failure (HF) hospitalisation, COAPT-like patients
- COAPT-like: moderate discrimination and good calibration
Non-COAPT-like patients · 2 years
- No progressive increase across quartiles; very poor discrimination and poor calibration
Original publication
Prediction of mortality and heart failure hospitalisations in patients undergoing M-TEER: external validation of the COAPT risk score. EuroIntervention. Published 24 April 2023. doi:10.
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