Prediction of atrial and ventricular arrhythmias using multiple cardiovascular risk-factor polygenic risk scores
Authors' conclusion
CV-PRS improved AF prediction compared to CHARGE-AF and AF-PRS. A CAD-PRS improved VA prediction, while CV-PRS contributed in IHD. AF- and CAD-PRS were transferable to individuals of South Asian ancestry.
Study context
- Population
- UK Biobank individuals of European, African, South Asian and East Asian ancestryEuropean ancestry
- Participants
- 158,733 individuals
- Comparison
- Clinical/demographic models with vs without AF-PRS, CAD-PRS and CV-PRS
- Outcome
- Prediction of incident atrial fibrillation (AF) and ventricular arrhythmia (C-index)
Methodological detailsUK Biobank, multi-ancestry validation, Performance evaluated in European (N = 158,733), African (N = 7200), South Asian (N = 9241) and East Asian (N = 2076) ancestry
- UK Biobank
- Multi-ancestry validation
- Performance evaluated in European (N = 158,733), African (N = 7200), South Asian (N = 9241) and East Asian (N = 2076) ancestry
Performance
As reported in the abstract
C-index, Europeans
AF1
0.746
C-index
AF2
0.762
C-index
AF3
0.765
C-index
VA1
0.681
C-index
VA2
0.692
C-index
AF2 vs AF1: P < 0.001 · AF3 vs AF2: P < 0.001 · VA2 vs VA1: P < 0.001
Further findings
| Outcome | P value |
|---|---|
| C-index, South AsiansAF2 vs AF1 · higher with AF2 | P < 0.001 |
| C-index, South AsiansVA2 vs VA1 · higher with VA2 | P < 0.001 |
Original publication
Prediction of atrial and ventricular arrhythmias using multiple cardiovascular risk-factor polygenic risk scores. Heart Rhythm. Published 15 December 2024. doi:10.
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