United States Pooled Cohort Cardiovascular Disease Risk Scores in Adults With Diabetes Mellitus
Authors' conclusion
Our U.S. pooled cohort DMRS for predicting CVD events demonstrated good predictive performance for assessing CVD risk in adults with DM.
Study context
- Population
- Cardiovascular disease (CVD)-free US adults with diabetes mellitus (DM) aged 40 to 79 years
- Participants
- 2,174 adults4 US cohorts
- Outcome
- 10-year DM Risk Scores (DMRS) for total CVD, ASCVD, CHD, HF and stroke: discrimination and calibration
- Follow-up
- Up to 10 years
Methodological detailspooled cohort, pooled 4 US population-based cohorts, internal and external validation, Participants: mean age 59.2 ± 10.5 years, 55.4% female, 47.5% Black; follow-up up to 10 years
- Pooled cohort
- Pooled 4 US population-based cohorts
- Internal and external validation
- Participants: mean age 59.2 ± 10.5 years, 55.4% female, 47.5% Black; follow-up up to 10 years
Performance
As reported in the abstract
DMRS internal performance
- C-statistic, CVD
- 0.72
- C-statistic, atherosclerotic CVD (ASCVD)
- 0.72
- C-statistic, coronary heart disease (CHD)
- 0.72
- C-statistic, heart failure (HF)
- 0.79
- C-statistic, stroke
- 0.73
- Calibration slope, CVD
- 0.93
- Calibration slope, ASCVD
- 0.95
- Calibration slope, CHD
- 0.93
- Calibration slope, HF
- 0.98
- Calibration slope, stroke
- 0.89
- Greenwood Nam-D'Agostino test significant for CHD
- P < 0.01
- Greenwood Nam-D'Agostino test significant for CVD
- P < 0.05
Further findings
External validation (2 other cohorts)
- DM Risk Scores (DMRS) outperformed current risk scores
Most important predictors
- Age, sex, HbA1c, creatinine, SBP, DM medication and smoking
Original publication
United States Pooled Cohort Cardiovascular Disease Risk Scores in Adults With Diabetes Mellitus. JACC Adv. Published 13 December 2024. doi:10.
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