Heart failure & cardiomyopathies
Predictive Value of NT pro BNP for New-Onset Atrial Fibrillation in Heart Failure and Preserved Ejection Fraction
Primary result · New-onset AFResult — go to the resultHazard ratio 1.16 95% CI 1.02–1.32Authors' conclusion
Among patients with HFpEF, the NT-proBNP level was positively associated with the incidence of new-onset AF and may be a promising predictor.
Study context
- Population
- Heart failure with preserved ejection fraction (HFpEF) patients without baseline atrial fibrillation (AF) from the TOPCAT trial
- Participants
- 367 patients
- Comparison
- NT-proBNP as predictor of new-onset AF
- Primary endpoint
- New-onset AF
- Follow-up
- Median 2.91 years
Primary result
As reported in the abstract
Hazard ratio
1.16
95% CI 1.02–1.32
NT-proBNP (per 1000 pg/mL increase)
HR 1.16 (95% CI 1.02–1.32)
Per 1000 pg/mL increase, as printed
- New-onset AF cases
- 17 (4.63%)
- C-statistic of NT-proBNP for new-onset AF at 3 years (moderate)
- 0.67
Further findings
Added value of NT-proBNP to risk scores for AF
- CHADS2 C-statistic
- 0.63
- CHADS2+NT C-statistic
- 0.69
- CHADS2+NT net reclassification index (NRI)
- 47.46%
- CHADS2+NT integrated discrimination improvement (IDI)
- 1.18%
- R2CHADS2 C-statistic
- 0.65
- R2CHADS2+NT C-statistic
- 0.70
- R2CHADS2+NT NRI
- 48.03%
- R2CHADS2+NT IDI
- 0.51%
- CHA2DS2-VASc C-statistic
- 0.67
- CHA2DS2-VASc+NT C-statistic
- 0.72
- CHA2DS2-VASc+NT NRI
- 49.41%
- CHA2DS2-VASc+NT IDI
- 0.86%
- C2HSET C-statistic
- 0.77
- C2HSET+NT C-statistic
- 0.80
- C2HSET+NT NRI
- 50.32%
- C2HSET+NT IDI
- 1.58%
Original publication
Predictive Value of NT pro BNP for New-Onset Atrial Fibrillation in Heart Failure and Preserved Ejection Fraction. ESC Heart Fail. Published 28 August 2024. doi:10.
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