Heart failure & cardiomyopathies
Predictors and outcomes of pacemaker implantation in patients with cardiac amyloidosis
Authors' conclusion
Conduction system disease requiring PPM is a common complication in CA that affects up to 20.6% of patients. QRS duration and IVS thickness are independently associated with PPM implantation.
Study context
- Population
- Patients with cardiac amyloidosis (571 ATTR, 216 amyloidosis (AL))
- Participants
- 787 patients
- Outcome
- Prevalence, incidence and predictors of time to permanent pacemaker (PPM) implantation
Methodological detailstwo European referral centres
- Two European referral centres
Main finding
As reported in the abstract
PPM implantation · median follow-up 21.7 months (IQR 9.6-45.2)
- Permanent pacemaker (PPM) before initial evaluation
- 81 (10.3%)
- New PPM implantation during follow-up
- 81 (10.3%)
- Median time to implantation
- 15.6 months (IQR 4.2-40)
- Complete AV block as most common indication
- 49.4%
- QRS duration as independent predictor of PPM, HR
- 1.03 (1.02 to 1.03), p<0.001 (95% CI)
- Interventricular septum (IVS) thickness as independent predictor of PPM, HR
- 1.1 (1.03 to 1.17), p=0.003 (95% CI)
Observational data: associations, not effects.
Further findings
12-month PPM prediction model (QRS duration and IVS thickness)
- C-statistic
- 0.71
- Calibration slope
- 0.98
Original publication
Predictors and outcomes of pacemaker implantation in patients with cardiac amyloidosis. Heart. Published 6 July 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →