Arrhythmias & electrophysiology
Predictors of arrhythmic events in hypertrophic cardiomyopathy patients with an implantable cardioverter defibrillator: a systematic review and meta-analysis
Authors' conclusion
Specific markers remain strong predictors of arrhythmic events in HCM patients with ICDs, but other traditional risk factors may lack predictive utility.
Study context
- Population
- Hypertrophic cardiomyopathy (HCM) patients with implantable cardioverter defibrillators (ICDs) (91% primary prevention and 9% secondary prevention), mean age 50 years
- Participants
- 3,297 patients · 12 studies
- Comparison
- Clinical, electrocardiographic, and imaging predictors of arrhythmic events in ICD recipients with HCM (pooled hazard ratios (HRs))
- Outcome
- Annual arrhythmic event rate
- Follow-up
- Mean 4 years
Methodological detailsrandom-effects model
- Random-effects model
Pooled result
As reported in the abstract
Annual arrhythmic event rate
5% [95% confidence interval (CI): 4-7%]
Further pooled results
Predictors of arrhythmic events
| Comparison | HR (95% CI) | |
|---|---|---|
| NSVTNon-sustained ventricular tachycardia | 2.19 (1.62–2.98) | |
| LVEF <50% | 1.91 (1.27–2.89) | |
| Intraventricular pressure gradient >30 mmHg | 1.92 (1.03–3.56) | |
| Secondary prevention indication | 2.18 (1.39–3.41) | |
| 0.20.5125Hazard ratio (log scale) |
Sensitivity analysis in the primary prevention subgroup
- Non-sustained ventricular tachycardia (NSVT) and left ventricular ejection fraction (LVEF) <50% consistently significant predictors
- Other traditional risk factors showed limited predictive value
Original publication
Predictors of arrhythmic events in hypertrophic cardiomyopathy patients with an implantable cardioverter defibrillator: a systematic review and meta-analysis. Eur Heart J Qual Care Clin Outcomes. Published 16 April 2025. doi:10.
Summarised from the published abstract; every number is checked against it