Predictors of Death in Contemporary Adult Patients With Eisenmenger Syndrome: A Multicenter Study
Authors' conclusion
There is significant premature mortality among contemporary adults with Eisenmenger syndrome.
Study context
- Population
- Adults with Eisenmenger syndrome under follow-up 2000–2015
- Participants
- 1,098 adults
- Exposure
- Posttricuspid vs Complex vs Pretricuspid
- Posttricuspidn = 643
- Complexn = 315
- Pretricuspidn = 140
- Outcome
- Death (survival and predictors of death)
- Follow-up
- Median 3.1 years
Main finding
As reported in the abstract
Independent predictors of death (multivariable Cox regression) · median follow-up 3.1 years (IQR 1.4-5.9)
Estimate (95% CI)P value
Age
HR 1.41 per 10 years(1.24–1.59)
P < 0.001Pretricuspid shunt
HR 1.56(1.02–2.39)
P = 0.041Oxygen saturation at rest
HR 0.53 per 10%(0.43–0.65)
P < 0.001Sinus rhythm
HR 0.53(0.32–0.88)
P = 0.013Pericardial effusion
HR 2.41(1.59–3.66)
P < 0.001Each row per its own increment, as printed
- Deaths
- 278
- Transplantation
- 6
- Patient-years of observation
- 4361.6
Observational data: associations, not effects.
Further findings
- Significant predictors of death on univariable analysis
- 12
Original publication
Predictors of Death in Contemporary Adult Patients With Eisenmenger Syndrome: A Multicenter Study. Circulation. Published 15 December 2016. doi:10.
Summarised from the published abstract; every number is checked against it