Preeclampsia, gestational hypertension, and cardiovascular disease risk: a genetic epidemiological study
Authors' conclusion
Genetic predisposition to hypertensive disorders of pregnancy was associated with greater risk of cardiovascular disease later in life
Study context
- Population
- Women; summary-level data from FinnGen and largest consortia; individual-level data from White British women in UK BiobankUK Biobank one-sample Mendelian randomization (MR)
- Participants
- 202,876 women
- Comparison
- Genetic predisposition to preeclampsia or gestational hypertension and CVD risk
- Outcome
- Two-sample MR
Methodological detailstwo-sample MR, one-sample MR, Genetic instruments from GWAS: 20 064 preeclampsia cases, 703 117 controls; 11 027 gestational hypertension cases, 412 788 controls
- Two-sample MR
- One-sample MR
- Genetic instruments from GWAS: 20 064 preeclampsia cases, 703 117 controls; 11 027 gestational hypertension cases, 412 788 controls
Main finding
As reported in the abstract
Odds ratio (95% CI)
Preeclampsiaischaemic heart disease
1.20(1.06–1.35)
PreeclampsiaMI
1.29(1.13–1.47)
Preeclampsiastroke
1.23(1.12–1.35)
Preeclampsiaischaemic stroke
1.21(1.10–1.33)
PreeclampsiaAF
1.13(1.01–1.25)
PreeclampsiaHF
1.11(1.04–1.20)
Gestational hypertensionischaemic heart disease
1.21(1.10–1.33)
Gestational hypertensionMI
1.26(1.16–1.36)
Gestational hypertensionstroke
1.30(1.23–1.37)
Gestational hypertensionischaemic stroke
1.24(1.17–1.32)
Gestational hypertensionAF
1.29(1.17–1.42)
Gestational hypertensionHF
1.09(1.03–1.15)
Further findings
One-sample MR (UK Biobank)
- Broadly consistent with the main findings
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Preeclampsia, gestational hypertension, and cardiovascular disease risk: a genetic epidemiological study. Eur Heart J. Published 3 September 2025. doi:10.
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