Pregnancy and Cardiac Maternal Outcomes in Women with Inherited Cardiomyopathy: Interest of the CARPREG II Risk Score
Authors' conclusion
Pregnancy in women with inherited cardiomyopathy carries a high risk of maternal cardiovascular complications. CARPREG II is the most efficient predictor of cardiovascular complications in this population.
Study context
- Population
- Pregnancies in women with inherited cardiomyopathy (dilated cardiomyopathy (DCM), hypertrophic, arrhythmogenic RV cardiomyopathy, LV noncompaction), excluding peripartum cardiomyopathypregnancies in 74 patients
- Participants
- 90 pregnancies
- Exposure
- CARPREG II vs CARPREG, mWHO and ZAHARA risk scores
- Outcome
- Severe cardiac maternal complications and discriminatory power of risk scores (AUC)
Methodological detailssingle-centre, consecutive pregnancies
- Single-centre
- Consecutive pregnancies
Main finding
As reported in the abstract
Severe cardiac maternal complications
| Group | AUC |
|---|---|
| CARPREG II | 0.782 |
| CARPREG | 0.755 |
| mWHO | 0.697 |
| ZAHARA | 0.604 |
AUC
CARPREG II0.782
CARPREG0.755
mWHO0.697
ZAHARA0.604
- Severe cardiac maternal complication
- 18 (20%) pregnancies
- Arrhythmia
- 10 pregnancies
- HF
- 10 pregnancies
- CV deaths
- 3
- CARPREG II significantly associated with cardiac maternal complications
- P < 0.05 for all
Observational data: associations, not effects.
Further findings
CARPREG II score
- Median CARPREG II score (higher in DCM subgroup)
- 2 [0;3]
Foetal/neonatal complications
- Foetal/neonatal complications
- Forty-three pregnancies (48%)
- Premature delivery
- 18
- Foetal/neonatal death
- 3
Original publication
Pregnancy and Cardiac Maternal Outcomes in Women with Inherited Cardiomyopathy: Interest of the CARPREG II Risk Score. ESC Heart Fail. Published 15 February 2024. doi:10.
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