Pregnancy in women with congenital heart disease: New insights into neonatal risk prediction
Authors' conclusion
One third of ACHD pregnancies are complicated by poor neonatal outcome. These complications are determined by four independent factors relating to the cardiac and non-cardiac status of the patients, which have been incorporated into a risk score.
Study context
- Population
- Women with adult congenital heart disease (ACHD) born 1975–1996 with ≥1 ACHD cardiology consultation at Cliniques Universitaires Saint-Luc
- Participants
- 491 pregnancies
- Exposure
- New neonatal risk model vs scores adapted from ZAHARA and CARPREG
- Outcome
- Neonatal complications
Methodological detailsrisk prediction model development, single-centre, bootstrap validation
- Risk prediction model development
- Single-centre
- Bootstrap validation
Main finding
As reported in the abstract
- Neonatal complications
- 31.4%
- Cardiac treatment during pregnancy, OR
- 14.8 (3.4-66) (95% CI)
- Hypertensive disorders of pregnancy, OR
- 11.4 (3.4-39.0) (95% CI)
- Smoking during pregnancy, OR
- 10.6 (2.8-40.6) (95% CI)
- Pre-pregnancy BMI <18.5 kg/m², OR
- 6.5 (2.5-16.5) (95% CI)
Observational data: associations, not effects.
Further findings
Risk model discrimination
- AUC (95% CI), stable after bootstrap validation
- 0.70 (0.65-0.75)
- Model significantly outperformed scores adapted from ZAHARA and CARPREG
- Risk score developed with five risk categories
Original publication
Pregnancy in women with congenital heart disease: New insights into neonatal risk prediction. Am Heart J. Published 26 April 2024. doi:10.
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