Arrhythmias & electrophysiology
Premature Ventricular Complexes After Ablation for Paroxysmal Atrial Fibrillation and Recurrent Atrial Arrhythmias: The admIRE Subanalysis
Main finding · Atrial arrhythmia recurrence (postblanking, days 91-365)Result — go to the resultOdds ratio 2.1 95% CI 1.2–3.5Authors' conclusion
Patients with PVCs in the first 6 months after catheter ablation for PAF are at higher risk for recurrent atrial arrhythmia. Whether PVCs themselves trigger atrial arrhythmias, or common underlying mechanisms trigger both, remains uncertain.
Study context
- Population
- Paroxysmal atrial fibrillation (PAF) patients undergoing pulsed field ablation with a variable-loop catheterpatients from admIRE, second study cohort N = 261 · admIRE 361 · second study (very high-power, short-duration radiofrequency ablation) 261
- Participants
- 361 patients
- Comparison
- As compared with patients without postablation premature ventricular complexes (PVCs), those with PVCs
- Postablation PVCsn = 135
- Outcome
- atrial arrhythmia recurrence (postblanking, days 91-365)
Methodological detailsLogistic regression models, core lab PVC assessment
- Logistic regression models
- Core lab PVC assessment
Main finding
As reported in the abstract
Odds ratio
2.1
95% CI 1.2–3.5
P = 0.006
Postablation PVCs vs without postablation PVCs
OR 2.1 (95% CI 1.2–3.5); P = 0.006
Further findings
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Recurrence, second study (very high-power, short-duration radiofrequency ablation)Early PVCs; N = 261 | 2.3 (1.2–4.6) | P = 0.015 | |
| 0.20.5125Odds ratio (log scale) |
Postablation PVCs prior to day 180
- Patients with postablation PVCs
- 135 (37.5%)
Original publication
Premature Ventricular Complexes After Ablation for Paroxysmal Atrial Fibrillation and Recurrent Atrial Arrhythmias: The admIRE Subanalysis. JACC Clin Electrophysiol. Published 28 May 2025. doi:10.
Summarised from the published abstract; every number is checked against it