Pre-existing maternal cardiovascular disease and the risk of offspring cardiovascular disease from infancy to early adulthood
Main finding · Offspring CVDResult — go to the resultAdjusted hazard ratio 2.09 95% CI 1.83–2.39Authors' conclusion
Maternal CVD was associated with an increased risk of CVD in offspring during childhood and young adulthood.
Study context
- Population
- Live singletons without major malformations or congenital heart disease born 1992–2019 in Swedenoffspring analysed
- Participants
- 2,597,786 singletons
- Exposure
- Maternal pre-existing cardiovascular disease (CVD) vs no maternal CVD
- Maternal CVDn = 26,471
- Outcome
- Offspring CVD from infancy to early adulthood
- Follow-up
- Median 14 years (range 1-29 years)
Methodological detailsregister-based, negative control (paternal CVD)
- Register-based
- Negative control (paternal CVD)
Main finding
Offspring CVD
Adjusted hazard ratio
2.09
95% CI 1.83–2.39
Maternal CVDvs No maternal CVD
adjusted HR 2.09 (95% CI 1.83–2.39)
As reported in the abstract
- Offspring diagnosed with CVD (all)
- 17 382
Observational data: associations, not effects.
Further findings
Offspring CVD by paternal CVD (negative control)
| HR (95% CI) | ||
|---|---|---|
| Paternal CVDSmaller magnitude than maternal CVD · negative control | 1.49 (1.32–1.68) | |
| 0.512Hazard ratio (log scale) |
Offspring CVD by maternal CVD type
| HR (95% CI) | ||
|---|---|---|
| Maternal arrhythmia | 2.94 (2.41–3.58) | |
| Vascular | 1.59 (1.21–2.10) | |
| Structural heart diseases | 1.48 (1.08–2.02) | |
| 0.20.5125Hazard ratio (log scale) |
Original publication
Pre-existing maternal cardiovascular disease and the risk of offspring cardiovascular disease from infancy to early adulthood. Eur Heart J. Published 4 September 2024. doi:10.
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