Prenatal Urban Environment and Blood Pressure Trajectories From Childhood to Early Adulthood
Authors' conclusion
Replicated findings suggest that higher prenatal humidity and temperature could modulate blood pressure changes across childhood.
Study context
- Population
- Participants of a UK birth cohort, with BP measured repeatedly from childhood to early adulthoodreplication up to 9,261
- Participants
- 7,454 participants
- Exposure
- Prenatal urban environmental exposures and BP trajectories
- Outcome
- Trajectories of SBP and DBP (change over time)
- Follow-up
- Childhood to early adulthood
Methodological detailsexposome-wide association study, replication in 4 independent European cohorts, Linear spline mixed-effects models
- Exposome-wide association study
- Replication in 4 independent European cohorts
- Linear spline mixed-effects models
Main finding
As reported in the abstract
SBP change in childhood (discovery)
Mean yearly change in SBP, mm Hg/y (95% CI)
Humidity (per IQR increase)faster increase
0.29(0.20–0.39)
Temperature (per IQR increase)slower increase
−0.17(−0.28 to −0.07)
Per IQR increase, as printed
Observational data: associations, not effects.
Further findings
Replication in other cohorts
- Results for humidity and temperature replicated; air pollution not replicated
Original publication
Prenatal Urban Environment and Blood Pressure Trajectories From Childhood to Early Adulthood. JACC Adv. Published 8 January 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →