Prevalence and clinical correlates and characteristics of “Super Fontan”
Authors' conclusion
The prevalence of SF gradually decreased over time. SF was characterized by preserved multi-end-organ function and an excellent prognosis. Pre-Fontan hemodynamics and post-Fontan childhood daily activity were associated with being adult SF.
Study context
- Population
- Fontan patients who had undergone cardiopulmonary exercise testing
- Participants
- 404 patients
- Exposure
- Super-Fontan (SF) vs non-SF
- SFn = 77
- Outcome
- Prevalence of SF
Main finding
As reported in the abstract
| Group | Value | Postoperative 5 years | Postoperative 10 years | Postoperative 15 years | Postoperative 20 years | Postoperative ≥ 25 years |
|---|---|---|---|---|---|---|
| SF | 19% | 16 (35%) | 30 (39%) | 18 (19%) | 13 (14%) | 0 (0%) |
SF
Value19%
Postoperative 5 years16 (35%)
Postoperative 10 years30 (39%)
Postoperative 15 years18 (19%)
Postoperative 20 years13 (14%)
Postoperative ≥ 25 years0 (0%)
Observational data: associations, not effects.
Further findings
| Outcome | SF |
|---|---|
| Death and unexpected hospitalization during follow-up | |
| Hospitalization rate | 67% lower than non-SF |
- Death and unexpected hospitalization during follow-up — Deaths overall
- 25
- Death and unexpected hospitalization during follow-up — Unexpected hospitalizations overall
- 74
- Death and unexpected hospitalization during follow-up — SF vs non-SF death and hospitalization
- P < .01-.001
Clinical correlates of SF vs non-SF
- SF patients younger
- P < 0.001
- SF patients mostly men
- P < 0.05
- SF: high arterial BP and saturation (SaO2), low systemic ventricle (SV) end-diastolic pressure, favorable body composition, superior pulmonary function, preserved hepatorenal and hemostatic functions, better glucose tolerance
- P < 0.05-.001
- Pre-Fontan better SV function, low pulmonary artery resistance and high SaO2 associated with current SF
- P < 0.05-.01
- Positive trajectory of exercise capacity and high daily activity during childhood associated with current adult SF
- P < 0.05
Original publication
Prevalence and clinical correlates and characteristics of “Super Fontan”. Am Heart J. Published 20 May 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →